Micky van de Ven Double Halts The Toffees' Run at Brand New Stadium
Micky van de Ven became the initial defender to score two goals in a Premier League match for Tottenham since Jan Vertonghen in spring 2013.
At a glance
Micky Van de Ven heads home twice in first half
Everton's Jake O'Brien has goal disallowed after VAR review
Senegalese midfielder scores final goal in 89th minute
This loss is Everton's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Tottenham extended their winning streak in away games in the top division and handed the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their new ground at Bramley-Moore Dock, having left their historic home behind after 133 years at the conclusion of the previous campaign.
But Spurs captain Van de Ven pounced twice from corners in the first half to put their impressive record at jeopardy, and they were unable to turn it around before the midfielder - assisted by former Toffees attacker Richarlison - nodded in a final goal to seal the victory.
The Everton defender thought he had levelled the tally five minutes after the defender's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, in the meantime, failed to convert a number of chances, while Vicario made a succession of fine stops to ensure the London club went five matches on the road unbeaten in the Premier League.
But the VAR stepped in, instructing Craig Pawson to review the goal on the screen and the official decided that the winger and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
This victory moves the manager's side up to third in the division, five points off north London rivals and leaders Arsenal.
Everton stay in 14th position and sit half a dozen points clear of the relegation zone.
Tottenham analysis: The defender fulfils role at both ends of the field
After a uninspiring weekday performance in the European competition against the French side, where they mustered a only attempts on goal, the manager opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it emerged he wasn't needed in the end.
Defender Van de Ven transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the face of goal for an free the defender to score.
And the captain - filling in as skipper in Cristian Romero's absence - added his next goal in added time as he rose above the England keeper to head home.
Van de Ven was equally outstanding in defence, combining effectively with his defensive colleague as the duo dealt superbly with the 34 crosses thrown their way by Everton.
Everton analysis: Toffees missing finishing touch
The club's new home had been a happy hunting ground, but it appears the novelty may have worn off slightly and supporters headed to the exits after the midfielder's final goal for Tottenham.
The break in Everton's unbeaten home run will not be a major concern for the manager, but their striker situation are.
The forward and the other striker - the Everton's two established strikers - had netted just a single goal between them before Sunday's outing.
And they were failed to add to that miserable record on a damp and dreary evening on in Liverpool.
Beto's performance was epitomized when he chose to bicycle-kick a clear chance from near the goal, despite having space and opportunity to readjust for a simpler attempt that would have tested Vicario.
The substitute, as well, failed to make an impact after replacing Beto in the second half.
It wasn't for a lack of opportunity. Most of the home side's attacks came through the winger and the forward, who tirelessly delivered dangerous crosses into the Spurs box.
What next for both teams?
Everton: The team head to Sunderland in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: The London club travel to St James' Park on late October for their fourth-round League Cup match against Newcastle.